Depends on how deep your pockets are and who you're going to be out with.
Del Frisco's Steakhouse: quality steak and has a great reputation
Abe & Arthur's: In the meatpacking district, very cool, very expensive, really fit women.
Kittichai: In Soho and again very cool and expensive, probably best to go in couples.
Balthazar: Soho, really good place for a hangover brunch, lunch.
Pastice: similar concept to Balthazar but more in Midtown. Open really late so good to go there after a bar/club.
Grammercy Hotel: has an amazing rooftop bar
Don't know where you are staying but we stayed in the London NYC which was a superb hotel, and the bar there wasn't too shabby either. Some of the hotel bars are the best so the W Hotels have good bars and the Hudson has a very cool bar as well.
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